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Metabolic Control Through the Pgc-1 Review Family of Transcription Coactivators

Written By Tuesday 19 April 2022 Add Comment Edit

Abstract

Peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-one) is an inducible co-regulator of nuclear receptors and is involved in a wide diversity of biological responses. Every bit the principal regulators of mitochondrial biogenesis and office, PGC-1α and PGC-1β accept been reported to play central roles in bone metabolism. They can be speedily induced under conditions of increased metabolic activities, such as osteoblastogenesis and osteoclastogenesis, to fulfill greater free energy demand or facilitate other biochemical reactions. PGC-1α and PGC-1β have both overlapping and distinct functions with each other amidst their target organs. In bone homeostasis, PGC-1α and PGC-1β promote the expression of genes required for mitochondrial biogenesis via coactivator interactions with key transcription factors, respectively regulating osteoblastogenesis and osteoclastogenesis. Hither, nosotros review the electric current understanding of how PGC-1α and PGC-1β bear upon osteoblastogenesis and osteoclastogenesis, how these two PGC-i coactivators are regulated in bone homeostasis, and how nosotros can interpret these findings into therapeutic potential for bone metabolic diseases.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China [grant numbers 81870737], Natural Scientific discipline Foundation of Guangdong Province, People's republic of china [grant numbers 2021A1515011779], Guangdong Financial Fund for High-Caliber Hospital Construction [grant numbers 174-2018-XMZC-0001-03-0125/D-02], and National Natural Science Foundation of Cathay [grant numbers 81771098].

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Affiliations

  1. Hospital of Stomatology, Sun Yat-Sen University, 56 Lingyuan 11 Route, Guangzhou, 510055, China

    Haoling Chen, Wenguo Fan & Fang Huang

  2. Guangdong Provincial Fundamental Laboratory of Stomatology, Guanghua Schoolhouse of Stomatology, Sun Yat-Sen Academy, 74 Zhongshan Rd 2, Guangzhou, 510080, China

    Haoling Chen, Wenguo Fan, Hongwen He & Fang Huang

Corresponding authors

Correspondence to Hongwen He or Fang Huang.

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Chen, H., Fan, W., He, H. et al. PGC-1: a key regulator in bone homeostasis. J Os Miner Metab 40, 1–8 (2022). https://doi.org/10.1007/s00774-021-01263-due west

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  • DOI : https://doi.org/10.1007/s00774-021-01263-w

Keywords

  • PGC-1α
  • PGC-1β
  • Mitochondrial biogenesis
  • Osteoblastogenesis
  • Osteoclastogenesis

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